The University of Science and Technology succeeded the Kumasi College of Technology which was established by a Government Ordinance on 6th October, 1951. It was however, opened officially on 22nd January, 1952 with 200 Teacher Training students transferred from Achimota, to form the nucleus of the new College.
In October, 1952, the School of Engineering and the Department of Commerce were established and the first students were admitted. From 1952 to 1955, the School of Engineering prepared students for professional qualifications only. In 1955, the School embarked on courses leading to the University of London Bachelor of Engineering External Degree Examinations.
The University is situated approximately on a sixteen square-kilometre campus of undulating land and pleasant surroundings, about seven kilometres away from the central business district of the city of Kumasi. The campus presents a panorama of beautiful and modern buildings interspersed with verdant lawns and tropical flora, which provide a cool and refreshing atmosphere congenial to academic studies. It has within the short period of its existence become an important centre for the training of scientists and technologists not only for Ghana, but also for other African countries as well as from other parts of the world.